Società Italiana di Biofisica e Biologia Molecolare

SIBBM 2022 • Frontiers in Molecular Biology

The RNA World 3.0

Rome, Italy · 20-22 June 2022

Società Italiana di Biofisica e Biologia Molecolare

SIBBM 2022
Frontiers in Molecular Biology

The RNA World 3.0

Rome, Italy · 20-22 June 2022


  • Monday, 20 June 2022

    13:00-13:15 Welcome Addresses
    Session I - RNA structure, localization and RNA-protein interaction
    CHAIRS: Valeria Poli and Francesco Nicassio
    13:15-13:45 Fabrizio d'Adda di Fagagna, IFOM, Milan & IGM-CNR, Pavia, Italy
    Telomeric non coding RNA biology offers therapeutic opportunities
    13:45-14:15 The Giovanni Armenise-Harvard Foundation Lecture
    Marie Laure Baudet, Department CIBIO, University of Trento, Trento, Italy
    ncRNAs: a non-canonical mode of intracellular transport through organelle hitchhiking
    14:15-14:30 Eleonora D'Ambra, IIT, Rome, Italy
    Circ-Hdgfrp3 travels along motor neuronal processes and is included in cytoplasmic assemblies formed by ALS-associated mutant FUS protein
    14:30-14:45 Marianna Maniaci, IEO, Milan, Italy
    The impact of arginine methylation in phase separation and RNA binding proteins dynamics in the context of cisplatin-induced genotoxic stress
    14:45-15:05 Coffee break
    15:05-15:35 Gian Gaetano Tartaglia, IIT & Sapienza University of Rome, Italy
    Towards the discovery of RNA interactions involved in phase separation
    15:35-16:05 Human Technopole Lecture
    Michaela Zavolan, Biozentrum, University of Basel, Switzerland
    Cell-type-specific expression of 3’ UTR isoforms: quantification, modelling, prediction of functional relevance
    16:05-16:20 Damiano Mangoni, IIT, Genoa, Italy
    L1 RNAs regulate cortical development by tuning PRC2 activity
    16:20-16:35 Giorgio Giardina, Sapienza University of Rome, Italy
    Riboregulation as a new player in the control of cellular metabolism: clues from the cryo-EM structure of serine hydroxymethyltransferase-RNA complex
    16:35-16:50 Alessandro Rosa, Sapienza University of Rome, Italy
    An aberrant interplay among RNA-binding proteins in amyotrophic lateral sclerosis
    16:50-17:00 Talks by sponsors
    17:00-18:30 Poster Session 1 (even numbers)
    18:30-20:00 Symposium: Science and Society
    L'RNA nell'era della medicina di precisione

    Barbara Gallavotti (giornalista)
    Rino Rappuoli (Chief Scientist and Head External R&D, Center GSK Vaccines Italy)
    Ennio Di Gregorio (Head of Research and Development, Center GSK Vaccines Italy)
    Giuseppe Ippolito (Direttore Generale, Direzione generale della ricerca e dell'innovazione in sanità, Ministero della Salute)
    The Organisers

    20:30 Social Dinner - Casa dell’aviatore
  • Tuesday, 21 June 2022

    Session II - Non coding RNA functions and mechanisms
      Long non coding RNAs and Circular RNAs
    CHAIRS: Irene Bozzoni and Salvatore Oliviero
    9:00-9:30 Igor Ulisky, Weizmann Institute, Rehovot, Israel
    Functions and modes of action of long noncoding RNAs in mammalian cells
    9:30-10:00 Joshua Mendell, UT Southwestern Medical Center, Dallas, USA
    Regulation and function of noncoding RNAs: lessons from NORAD
    10:00-10:15 Andrea Lauria, University of Turin, Italy
    The non-coding RNA lncSmad7 recruits the acetyltransferase p300 to enhancers of genes involved in the control of stem-cell identity
    10:15-10:30 Agnese Loda, EMBL, Heidelberg, Germany
    Dissecting the regulatory landscape of genes that resist X-chromosome inactivation
    10:30-10:50 Coffee break
      Long non coding RNAs and Circular RNAs (cont.)
    10:50-11:20 Piero Carninci, Genomics Research Center, Functional Genomics Programme at Human Technopole, Milan, Italy
    Long non-coding RNAs, from interactome to function
    11:20-11:50 Beatrice Bodega, Dept of Biosciences, University of Milan & INGM, Italy
    Transcription and dynamics of Transposable Elements keeps on fire the genome of human T lymphocytes
    11:50-12:05 Manuel Beltran Nebot, Sapienza University of Rome, Italy
    The circular RNA ZNF609 regulates microtubule dynamics and tumorigenicity by sustaining CKAP5 protein levels
    12:05-12:20 Marta Biagioli, University of Trento, Italy
    Faulty linear and back-splicing in Huntington’s disease: novel players in the pathologic process hint at innovative RNA biomarkers
      WORKSHOP: Direct RNA Sequencing
    CHAIRS:  Francesco Nicassio and Logan Mulroney (IIT and EBI/EMBL)
    12:20-12:40 Camilla Ugolini, IIT Milan, Italy
    Nanopore ReCappable Sequencing maps SARS-CoV-2 5ʹ capping sites and provides new insights into the structure of sgRNAs
    12:40-13:00 Sìlvia Carbonell Sala, CRG, Barcelona, Spain
    Expanding GENCODE lncRNA gene catalog with the CapTrap-Capture Long Seq in human and mouse
    13:00-13:15 Adriano Fonzino, University of Bari, Italy
    Assessing potential feasibility of Nanopore Sequencing platform for the detection of Ribonucleotides in DNA molecules
    13:15-14:30 Lunch
      Small RNAs and RNA modifications
    CHAIRS: Marie Laure Baudet and Fabrizio d'Adda di Fagagna
    14:30-15:00 Anders Lund, University of Copenhagen, Denmark
    Tuning the ribosome in health and disease
    15:00-15:30 Andrea Ventura, Sloan Kettering Institute, New York, USA
    Non-coding RNAs, chromosomal rearrangements, and cancer
    15:30-15:45 Isaia Barbieri, University of Cambridge, UK
    The mRNA 5’- cap methyltransferase TGS1 regulates redox metabolism in Acute myeloid leukaemia
    15:45-16:00 Bianca Pierattini, SISSA, Trieste and IIT, Genoa
    N6-methyladenosine modification regulates SINEUP lncRNAs activity
    16:00-16:10 Talks by Sponsors
    16:10-16:30 Coffee break
    16:30-17:00 Alessandro Fatica, Sapienza University of Rome, Italy
    Impact of m6A modulation in cancer: a lesson from chronic myeloid leukemia
    17:00-17:30 Ana Boskovic, EMBL Rome, Italy
    The role of tRNA fragments in intergenerational epigenetic inheritance
    17:30-17:45 Bianca Giuliani, IIT, Milan, Italy
    A functional map of long non-coding RNAs involved in adaptation pathways of breast cancer cells
    17:45-18:00 Roberta Cacioppo, University of Cambridge, UK
    Unbalanced alternative polyadenylation coupled to miRNA targeting drives oncogenic Aurora Kinase A (AURKA) overexpression
    18:00-19:30 Poster Session 2 (odd numbers)
    19:30-20:30 SIBBM Members' General Assembly
  • Wednesday, 22 June 2022

    Session III - RNA technology and therapeutics
    CHAIR: Stefano Gustincich and Michela A. Denti
    9:00-9:30 Reuven Agami, Netherlands Cancer Institute, Amsterdam, The Netherlands
    Sloppiness in mRNA translation in cancer
    9:30-10:00 Franck Slack, Harvard University, Boston, USA
    Toward Personalized microRNA Therapeutics
    10:00-10:30 Danny Incarnato, GBB, Groningen, The Netherlands
    High-throughput discovery of static and dynamic RNA structure elements
    10:30-10:45 Davide Mariani, IIT, Genoa, Italy
    Shipped to the wrong address: the impact of ALS-related FUS mutations on the subcellular RNA localization and membrane-less compartments composition
    10:45-11:00 Paola Falletta, DiBiT, HSR, Milan, Italy
    Road to metastasis: alternative mRNA translation regulates Triple-Negative Breast Cancer bioenergetics
    11:00-11:20 Coffee break
    11:20-11:35 Gaspare La Rocca, Memorial Sloan Kettering Cancer Center, New York, USA
    Manipulating the miRISC during tumor development
    11:35-11:50 Giuseppina Covello, University of Padua, Italy
    Exon skipping through chimeric antisense U1snRNAs to correct Retinitis Pigmentosa GTPase-Regulator (RPGR) Splice defect
    11:50-12:05 Mattia Furlan, IIT, Milan, Italy
    Inference of transcriptional and post-transcriptional dynamics from sequencing experiments
    12:10-12:45 Riccardo Cortese Lecture
    Willeke M.C. van Roon-Mom, Dutch Centre for RNA Therapeutics, Leiden, The Netherlands
    Splice modulating RNA targeting therapies for brain disorders; from treating many to treating one
    12:45-13:15 EMBL Lecture
    Adrian Krainer, Cold Spring Harbor Laboratory, USA
    Antisense therapeutics for genetic diseases and oncology
    13:15-13:45 Prizes and Wrap-up

    When preparing your poster, please remember that its maximum size is 90 x 120 cm (width x height). Note that the orientation is portrait, not landscape.

    Correct format... poster should be PORTRAIT  poster should NOT be LANDSCAPE Wrong format...

    Posters with an even number can be on display from noon on Monday (20 June) until noon on Tuesday (21 June) and will be presented during Poster Session 1 (Monday, 20 June, 17:00-18:30). Posters with an odd number can be on display from 12:30 on Tuesday (21 June) until 12:30 on Wednesday (22 June) and will be presented during Poster Session 2 (Tuesday, 21 June, 18:00-19:30). Posters that are not removed at the end of the time indicated above will be removed and discarded by the venue personnel.

    P.1 Roberto Albanese, Milan
    Towards isoform-level translation regulation

    P.2 Magdalena Arnal Segura, Genoa
    RNA transcripts of amyloid, stress granule proteins and neurodegenerative related genes present an enrichment of interactions with RNA binding proteins with distinct regulatory patterns

    P.3 Sidra Asghar, Bologna
    Altered snoRNA expression in NASH associated Hepatocellular carcinoma

    P.4 Nikolaos Balatsos, Larissa, Greece
    A splice variant of poly(A)-specific ribonuclease from pleural malignant mesothelioma

    P.5 Francesco Ballesio, Rome
    Investigating the possibility of a modular organization of lncRNA human genes by exon sequence and structure global alignments

    P.6 Cristina Barbagallo, Catania
    VECTOR: an integrated correlation network database for the identification of ceRNA axes in uveal melanoma

    P.7 Chiara Barzan, Pavia
    A novel circuit driving aberrant ovarian cancer vasculature

    P.8 Rosalia Battaglia, Catania
    A novel silicon platform for selective isolation, quantification, and molecular analysis of small extracellular vesicles

    P.9 Anna Mary Benedetti, Cambridge, United Kingdom
    The role of ribosomal protein WBSCR22 as a methyltransferase regulator in cancer

    P.10 Carlotta Bon, Genoa
    SINEUPs: a novel toolbox for RNA-based therapy of neurodegenerative diseases

    P.11 Giulio Bontempi, Rome
    Restoration of WT1/miR-769-5p axis by HDAC1 inhibition promotes MMT reversal in mesenchymal-like mesothelial cells

    P.12 Virginia Brancato, Milan
    Dissecting the transcriptome and epigenome of patient derived triple negative breast cancer organoids enables the investigation of tumor heterogeneity

    P.13 Ilaria Brentari, Trento
    Switching Tau splicing isoforms via siRNAs: therapeutic approaches for FTDP-17 neurodegenerative disorders

    P.14 Giulia Buonaiuto, Rome
    LncRNAs in heart development: how RNA epigenetics influences cardiomyocytes maturation to prevent cardiac hyperplasia

    P.15 Stefano Cagnin, Padua
    Non-coding RNAs participate to the maintenance of neuronal-muscle contacts impacting on muscle trophism

    P.16 Angela Caponnetto, Catania
    Down-regulation of long non-coding RNAs in reproductive aging and analysis of the lncRNA-miRNA-mRNA networks in human cumulus cells

    P.17 Martina Carnevale, Borgovirgilio
    Molecular profiles of human breast cancer and their association with tumour subtypes and disease prognosis

    P.18 Marta Ceccon, Milan
    Exploring the mechanism of 53BP1 liquid-liquid phase separation and its regulation by RNA

    P.19 Manuela Cervelli, Rome
    Role of Circular Spermine Oxidase RNAs in skeletal muscle physiopathology

    P.20 Alessia Ciarrocchi, Reggio Emilia
    Linc00941 supports Malignant Pleural Mesothelioma (MPM) progression by balancing cellular structure and response to stress

    P.21 Chiara Cicconetti, Turin
    3plex enable deep computational investigation of triplex forming lncRNAs

    P.22 Davide Colaianni, Padua
    miR-210 knock-out leads to retinal degeneration in Drosophila melanogaster and mice

    P.23 Angelo Giuseppe Condorelli, Rome
    Pro-fibrotic microRNAs in recessive dystrophic epidermolysis bullosa: a tale of epigenetically shaped clinical phenotypes, intertwined RNA networks and therapeutic perspectives

    P.24 Lucia Coscujuela Tarrero, Milan
    The Role of N6-Methyladenosine in Mediating Drug Resistance of Human Hepatocellular Carcinoma

    P.25 Stefano Cretti, Trento
    Involvement of RP11-334E6.12 lncRNA in gastric cancer pathogenesis

    P.26 Claudia Crosio, Sassari
    Effects of environmental triggers in amyotrophic lateral sclerosis cellular models: transcriptome analysis by RNA-seq

    P.27 Michele Cugusi, Turin
    Gene co-expression networks’ hubs as therapeutic targets for basal-like breast cancer

    P.28 Sabrina D'Agostino, Genoa
    Internal ribosome entry site RNAs act in trans through an antisense sequence in linear and circular non-coding RNAs

    P.29 Sara D'Uva, Rome
    From interactome to function: investigating the role of a motoneuronal circRNA

    P.30 Dario Dattilo, Rome
    The m6A reader YTHDC1 and DDX5 promote circRNA expression in rhabdomyosarcoma

    P.31 Vito Nicola De Pinto, Catania
    Voltage Dependent Anion selective Channels: an up-to-date view

    P.32 Fabio Desideri, Rome
    Noncoding RNA shaping gene expression: implications in motor neurons specification

    P.33 Valeria Di Gioia, Milan
    Unveiling the chromatin organization mediated by LINE1 elements in human T-cell quiescence

    P.34 Daniela Di Girolamo, Naples
    Molecular distinctions of extraocular muscle satellite cells

    P.35 Anna Di Matteo, Pavia
    A hierarchy of splicing factors integrating angiogenesis decisions

    P.36 Jessica Michaela Doering, Trento
    CircHTT, a novel circular RNA molecule from the Huntington’s disease gene locus: functional characterization and possible implications for disease progression

    P.37 Stefano Espinoza, Genoa
    Multi-BD-SINEUP RNA targets multiple mRNAs at the same time: proof of concept for 22q.11.2 deletion syndrome

    P.38 Vanessa Vera Fain, Rome
    RNA-seq study to identify differentially expressed genes in human fibroblasts exposed to 5,3 GHz

    P.39 Lucia Falbo, Milan
    Transcription-replication interference: implications for genome integrity

    P.40 Maria Sofia Falzarano, Ferrara
    Dystrophin mRNA in DMD muscle cells demonstrates unbalanced nuclear/cytoplasmic repartition leading to nuclear sequestration

    P.41 Alessandro Ferrando, Trieste
    SFPQ controls genomic stability by suppressing RNA:DNA hybrids in human cancer cells

    P.43 Ermes Filomena, Bari
    Deregulated lncRNAs in Alzheimer’s Disease inferred by weighted gene co-expression network analysis

    P.44 Antonio Francavilla, Candiolo, TO
    Gluten-free diet affects faecal small non-coding RNA profiles and microbiome composition in celiac disease supporting a host-gut microbiota cross-talk

    P.45 Lorenzo Franchitti, Orbassano, TO
    A computational pipeline for functional analysis of alternative splicing events

    P.46 Sofia Francia, Pavia
    DROSHA and DICER RNA products control BMI1-dependent transcriptional repression at DNA damage sites

    P.47 Angela Gallo, Rome
    ADAR1 is a new target of METTL3 and plays a pro-oncogenic role in glioblastoma by an editing-independent mechanism

    P.48 Anna Gambetta, Padua
    A genome-wide screening in pluripotent cells identifies Mtf1 as a novel suppressor of mutant huntingtin toxicity

    P.49 Paolo Gandellini, Milan
    Pancancer overexpression of the novel in cis-acting and cell cycle-regulated NFYC-AS1 antisense long noncoding RNA

    P.50 Sabrina Garbo, Rome
    lncRNA HOTAIR-based approach to counteract EMT

    P.51 Jessica Gasparello, Ferrara
    Diagnostic and therapeutic role of microRNAs in colorectal cancer: from liquid biopsy to the development of a novel miRNA-based therapeutic protocols

    P.52 Silvia Gasparini, Rome
    Insights into the neuronal circRmst

    P.53 Roberto Giambruno, Segrate
    RNA-host protein interaction analyses reveal additional proteins involved in SARS-CoV-2 RNA biology

    P.54 Claudio Lo Giudice, Bari
    UTRdb 3.0 a comprehensive, expert curated catalog of eukaryotic mRNAs untranslated regions

    P.55 Andrea Giuliani, Rome
    The role of m6A in stress granules dynamics in ALS

    P.56 Stefano Giuliani, Rome
    Transcriptomic profiling of non-coding RNAs in the Dach-SMOX mouse brain cortex

    P.57 Alessia Grandioso, Rome
    Use of circular RNAs in vaccine treatments

    P.58 Francesco Greco, Rome
    Identification of a SARS-CoV-2 encoded miRNA originating from the minus strand of the viral genome

    P.59 Chiara Grelloni, Rome
    Role of circular RNA HIPK3 in Alveolar Rhabdomyosarcoma

    P.60 Alessia Iaiza, Rome
    Role of m6A-dependent circRNAs during stress response in acute myeloid leukemia progenitor cells

    P.61 Luca La Via, Brescia
    Role of CYFIP2 K/E RNA editing in neuronal cells function and morphology

    P.62 Pietro Laneve, Rome
    Identification and characterization of pathological long noncoding RNAs in brain cancer

    P.63 Davide Lecca, Milan
    Inhibition of miR-125a-3p improves myelin repair in animal models of multiple sclerosis

    P.64 Francesca Romana Liberati, Rome
    “A RNA-based inhibitor for human Serine Hydroxymethyltransferase targeting”

    P.65 Michela Lo Conte, Catanzaro
    Identification and molecular characterization of Retinoic Acid-responsive Zinc Fingers (ZNFs) regulating self-renewal and pluripotency of human pluripotent stem cells

    P.66 Andrea Lobascio, Turin
    STAT3-dependent pluripotency control via the stem-cell specific long non-coding RNA lincS1-PLATR10 and lincS3-LNCENC1

    P.67 Ludovica Lospinoso Severini, Rome
    miR-181a-5p, miR-324-5p, miR-451a, SMN2 full-length levels and SMN2 copy number: a molecular signature for spinal muscular atrophy patients

    P.68 Andrea Lunardi, Trento
    TRPM8 triggers sterile inflammation in prostate cells via TLR3/NF-kB axis

    P.69 Simone Maestri, Milan
    Benchmarking of tools for the detection of N6-Methyladenosine through direct Nanopore RNA sequencing

    P.70 Luigi Mansi, Bari
    REDIportal: the RNA editing comprehensive catalog

    P.71 Valeria Manzini, Rome
    Disease Modifying Therapy specifically impacts on microRNAs expression profiling in Relapsing-Remitting Multiple Sclerosis

    P.72 Davide Marangon, Milan
    MiR-125a-3p negatively regulates oligodendrocyte precursor cell maturation altering several pro-myelinating signaling pathways

    P.73 Barbara Mariotti, Verona
    NRIR drives the interferon-response in LPS-treated monocytes: mechanism of action and implication for Systemic Sclerosis

    P.74 Julie Martone, Rome
    Lnc-SMaRT, a new player in muscle differentiation

    P.75 Elisabetta Meacci, Florence
    miRNAs regulation by S1P signalling in skeletal muscle atrophy

    P.76 Fatima Mentucci, Fisciano, SA
    Implication of interferon-γ in TFF1 silencing during H. pylori chronic infection

    P.77 Valentina Miano, Cambridge, United Kingdom
    Targeting the m6A pathway as a new treatment strategy for ALK-positive lymphoma

    P.78 Stefania Modafferi, Pavia
    Mechanistic insights into the cause of DNA damage accumulation in cells bearing TDP-43 cytoplasmic inclusions

    P.79 Sara Morelli, Bologna
    Small-cell lung tumours repress transposable elements expression to restrict innate immune activation 

    P.80 Francesco Neri, Turin
    Novel mouse reporter to study RNA Polymerase II mediated transcription and cellular dormancy

    P.81 Carlos Nino, Milan
    Post-transcriptional splicing: a non-canonical way to modulate Alternative Splicing output in cancer

    P.82 Romina Oliva, Naples
    Modified nucleobases: structural and energetic impact on base pairing in RNA experimental structures

    P.83 Francesca Orso, Turin
    MiR-214 mediated stroma-tumor cell crosstalk during tumor progression

    P.84 Marta Pabis, Krakow, Poland
    ­­Study of lncRNA differential expression and targeting to EVs during cardio- and angiogenesis

    P.85 Simona Panni, Rende
    The annotation of ncRNA interactions in IntAct: Rare Diseases as a case study

    P.86 Chiara Papi, Ferrara
    Personalized medicine in Cystic Fibrosis: restore CFTR function by PNA-based miRNA targeting in combined treatments

    P.87 Simone Patscheider, Trento
    Cigarette smoking induces small airway epithelial epigenetic changes with corresponding modulation of gene expression

    P.88 Serena Peirone, Milan
    Molecular characterization of Osteosarcoma and Ewing sarcoma in pediatric patients reveals novel RNA-based intervention points

    P.89 Flaminia Pellegrini, Rome
    The KO of a motoneuron-specific lncRNA causes an in vivo locomotor impairment and the dysregulation of the ER stress response

    P.90 Laura Peretto, Ferrara
    Rescue of an F8 splicing variant (c.1752+5 G>C) with engineered U1snRNAs

    P.91 Sarah Perrone, Turin
    scGSECA: identification of altered biological processes in single-cell RNA-sequencing data by discretization of expression profiles

    P.92 Graziano Pesole, Bari
    Detecting C-to-U RNA editing by direct RNA sequencing

    P.93 Silvia Piscitelli, Naples
    The RNA-binding protein Lin28a: a multifunctional player in ESC fate

    P.94 Paola Piscopo, Rome
    Plasma circular RNA profiling in subjects with Alzheimer Disease and Mild Cognitive Impairment: a preliminary study on new possible diagnostic biomarkers

    P.95 Isabelle Polignano, Turin
    The role of long non-coding RNAs in cellular senescence

    P.96 Francesca Priante, Turin
    RNAmars: identification of multivalent RNA motifs and cognate regulators of alternative splicing

    P.97 Simone Procaccia, Genoa
    Single-cell multi-omic data integration: a case-study of triple-negative breast cancer

    P.98 Daniela Taverna, Turin
    Axl-miR-214sponge inhibits breast cancer dissemination

    P.99 Grazia Raffa, Rome
    SMN and TGS1 cooperate to preserve splicing fidelity and to counteract transcriptional stress and cell death in a Drosophila model for SMA

    P.100 Valeria Ranzani, Milan
    Identification of a LINE1-T exhaustion transcriptional signature in tumor-infiltrating lymphocytes at single cell resolution

    P.101 Jessica Rea, Rome
    Understanding the role of long noncoding RNAs in granule vs aggregate dynamics in Amyotrophic Lateral Sclerosis

    P.102 Giada Rossignoli, Padua
    Chemical conversion of human conventional pluripotent stem cells to trophoblast stem cells

    P.103 Marco Russo, Bologna
    DNA topoisomerase I poison camptothecin induces context-dependent R-loop changes in colon cancer cells

    P.104 Monia Russo, Rome
    Exploring the role of a lncRNA in Glioblastoma

    P.105 Alessandro Salvi, Brescia
    Expression profiling of selected cancer associated-ncRNAs in tissue and liquid biopsies from patients with human hepatocellular carcinoma

    P.106 Luana Scaramuzzino, Catanzaro
    Establishment of an in vitro model of Unverricht-Lundborg Disease (ULD) using induced pluripotent stem cells-derived neurons

    P.107 Mirko Giuseppe Scrivano, Turin
    Investigating the role of lncRNAs in neural differentiation and development

    P.108 Valentina Silenzi, Rome
    CircRNAs and brain function: investigating the role of circ-Dlc1

    P.109 Alessandro Simi, Genoa
    The PGBD5 DNA transposon is required for mouse cerebral cortex development

    P.110 Maria Francesca Testa, Ferrara
    Recoding of F8 premature termination codons in factor VIII B domain by translational readthrough result in residual expression levels contributing to lower their association with inhibitors

    P.111 Paolo Tollis, Rome
    Decoding the role of the lncRNA HOTAIRM1 in human motoneurons

    P.112 Elena Tonetto, Ferrara
    Base and Prime editing as innovative tools to revert point mutations leading to Hemophilia A

    P.113 Antonella Tramutola, Rome
    Role of miR-802 in brain insulin signaling and its impact on Down syndrome

    P.114 Chiara Tupini, Ferrara
    Proapoptotic activity on glioblastoma and colorectal cancer cell lines of antagomiRNAs combined with a new palladium complex

    P.115 Giulia Venturi, Bologna
    Primer extension coupled with fragment analysis to study 5.8S rRNA isoforms in a series of breast carcinoma samples

    P.116 Eleonora Vertecchi, Rome
    Nucleolar G-quadruplexes as targets in anti-cancer therapy

    P.117 Daniele Viavattene, Turin
    STAT3 is a master regulator of CAFs pro-oncogenic functions, acting via the induction of secreted proteins including ANGPTL4, MMP13 and STC1

    P.118 Emanuele Vitale, Reggio Emilia
    Coding or non-coding: evidence of the interplay between RUNX2 and its associated lncRNA RAIN

    P.119 Erika Vitiello, Genoa
    ”Stressing” the importance of live imaging to study RNA dynamics: use of fluorescent RNA aptamers to investigate the role of non-coding RNAs in neurodegeneration

    P.120 Adriano Voltolini, Trento
    Down syndrome and congenital heart disease: RNA-seq reveals differentially expressed cardiac tissue related genes

    P.121 Federico Zacchini, Bologna
    The pseudouridine synthase DKC1 binds to cytoplasmic transcripts containing H/ACA-box snoRNA sequences affecting nuclear hormone receptor dependence

    P.122 Clara Zannino, Catanzaro
    Induced pluripotent stem cells-derived neurons from a patient carrying c.434T>C mutation in SCN1A gene reveal molecular and electrophysiological immaturity

    P.123 Matteo Zurlo, Ferrara
    Targeting the microRNA network governing Glioblastoma: a possible miRNA-based combined approach for the precision therapy of GBM